Wnt-3a
[Wnt family member 3a; wingless-type MMTV integration site family member 3a] Wnt-3a is one member of the so-called Wnt family of proteins (Nusse et al, 1991). The human Wnt-3a gene has been identified by Saitoh et al (2001). The Wnt-3a protein shares 84.9 % sequence identity with human Wnt-3. The gene is expressed at moderate levels in placenta and at low levels in adult lung, spleen, and prostate. The gene is not expressed in any of 35 cancer cell lines examined (Saitoh et al, 2001).
LRP6 has been shown to act as a receptor for Wnt-3a (Yamamoto et al, 2006, 2008; Pan et al, 2008). Chacon et al (2008) have reported that frizzled-1
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