Frizzled |
frizzled-2 |
CYRL |
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[frizzled family receptor 1] this is a mammalian homolog of the Drosophila melanogaster frizzled proteins, which are known to interact with Wnt family proteins. frizzled-1 (647 amino acids) is known also as FzD1 or Fz1, and has been isolated from a human fetal lung cDNA library (Sagara et al, 1998). Human frizzled-1 has been shown to interact with several members of the Wnt family (Gazit et al, 1999). Wang et al (2005) have reported that Wnt-7b can bind to frizzled-1 and cooperatively activate canonical Wnt signaling in the presence of the LRP5
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