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This peptide, identified by phage display methods and termed F56 peptide by the authors, specifically binds to the VEGF receptor VEGFR1. The peptide almost abolishes VEGF binding to the VEGFR1 in vitro. In vivo, the peptide, fused with DHFR (DHFR-F56), inhibits angiogenesis in a Chicken chorioallantoic membrane assay assay and significantly inhibits the growth of nodules of human gastric cancer cell line MGC-803 in BALB/c nude mice, causing significant necrosis in the transplanted tumor. In a SCID mouse ... ... ... ...
 
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Entry last modified: March 2016