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VVGF

[vaccinia virus growth factor] VVGF, known also as Vaccinia 19 kDa protein (see: VGF, vaccinia growth factor), is detected in the medium of vaccinia-virus-infected cells. The factor is a processed form of a polypeptide encoded in the vaccinia virus genome which is related to EGF and TGF-alpha.

VVGF, unlike EGF or TGF, is glycosylated. VVGF binds to the EGF receptor and stimulates its autophosphorylation. and may, therefore allow the virus to subvert EGF receptor-dependent functions. VVGF can functionally replace MGF (myxoma growth factor). For a related gene encoded in the genome of cowpox virus see also: ... ... ... ... ... Subscribe to continue reading! ... ...

 

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