VEID

The sequence Val-Glu-Ile-Asp (VEID) corresponds to one of the caspase-6 cleavage sites of lamin A, a structural protein of the nuclear envelope that assists in maintaining the nuclear shape. The synthetic tetrapeptide VEID conjugated to 7-amino-4-trifluoromethyl coumarin (VEID-AFC) is a fluorometric substrate for caspase-6 enzyme activity which is detectable following cleavage of the substituted coumarin moiety from the peptide. VEID conjugated to 7-Amino-4-methyl coumarin (VEID-AMC) is a fluorogenic substrate for caspase-6. An enzyme that recognizes the VEID sequence is referred to sometimes also as VEIDase and would thus be caspasa-6 or possess caspase-6-like activity.

VEID-aldehyde ( ... ... ... ...
 
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Entry last modified: March 2014