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[Cytomegalovirus UL142 protein] This glycoprotein is encoded in the genome of human cytomegalovirus. The UL142 open reading frame is encoded within the ULb' region which is missing from a number of common high passage laboratory strains. UL142 is a viral MHC class 1-related molecule that is expressed late in infection. Knock-down of UL142 mRNA expression in HCMV-infected cells increases the sensitivity of cells to lysis by NK-cells, showing that the protein is involved in immune evasion as an ummunoevasin (Wills et al, 2005). UL142 prevents the surface expression of MICA [MHC class I chain related molecule A] (Chalupny et al, 2006), a ligand for NKG2D, a C-type lectin-like homodimer expressed on NK-cells and cytotoxic T-cells ... ... ... ... ... Subscribe to continue reading! ... ...


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