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U-995

U-995 has been purified from the cartilage of the blue shark (Prionace glauca). U-995 is composed of two single peptides with molecular mass of 10 kDa and 14 kDa.

U-995 markedly inhibits the migration of human umbilical cord endothelial cells, blocks cell proliferation, and blocks angiogenesis induced by TNF-alpha. The protein also markedly prevents collagenase-induced collagenolysis. Intraperitonal injection into mice suppresses sarcoma-180 cell growth and B16-F10 mouse melanoma cell metastasis in vivo (Sheu et al, 1998).

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