Toll-9

This Drosophila melanogaster protein, encoded by gene CG5528, belongs to the family of proteins related to the Toll receptor. Ooi et al (2002) have reported that wild-type Toll-9 behaves similar to gain-of-function mutations of Toll (Toll-1). Toll-9 activates strongly the expression of drosomycin, and utilizes similar signaling components to Toll-1 in activating the antifungal gene. The Toll-9 gene is expressed in adult and larval stages prior to microbial challenge, and the expression correlates with the high constitutive level of drosomycin mRNA in the animals. The authors have suggested that Toll-9 may be a constitutively active protein maintaining a substantial level of antimicrobial gene products ... ... ... ...
 
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Entry last modified: September 2013