Tetraspanin 30 |
tetrastatin |
tRNA-derived stress-induced RNAs |
||
[tetraspanin]
These proteins have a characteristic 4 membrane-spanning domain and constitute a large protein superfamily (Maecker et al, 1997; Wright and Tomlinson, 1994; Rubinstein, 2011). In addition, tetraspanins have short, cytosolic N-termini and C-termini and one small (EC1) and one large (EC2) extracellular loop. EC2 comprises 78 to 150 amino acids and contains 4 conserved cysteine residues (Boucheix C, Rubinstein, 2001).
Tetraspanins form clusters within the cell membrane. They aggregate withone another and also complex with a variety of other transmembrane proteins, in particular integrins. These clusters are known as the tetraspanin web or tetraspanin-enriched microdomains. Tetraspanins have been involved in the regulation of integrin-dependent cell migration, metastasis, and cell polarization, proliferation, and differentiation
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |
| SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
|
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R