TAN-1 |
Tanapoxvirus 15L protein |
MAP1ALC3 |
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abbr.: TPV-2L. This protein (Tanapoxvirus TNF binding protein) is an TNF binding protein encoded in the genome of Tanapoxvirus (Brunetti et al, 2003; Rahman et al, 2006). TPV-2L forms inhibitory complexes with human TNF-alpha. It also interacts with monkey and canine TNF with high affinity. It binds rabbit TNF with low affinity. TPV-2L inhibits human TNF-mediated signaling in cells. TPV-2L exhibits higher affinity for human TNF (KD = 43pM) compared to monkey TNF (KD = 120 pM
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