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TPO

[thrombopoietin] A general term, known also as TSF (thrombopoiesis stimulating factor) for mediator substances that function as natural stimulators of megakaryocytopoiesis and, thus, promote the differentiation of platelets (see also: hematopoiesis). The approved gene symbol is THPO.

TPO stimulates an increase in the sizes and numbers of megakaryocytes, DNA content, endomitosis, and maturation. It also increases the number of small acetyl-cholinesterase positive cells that are early precursor cells of the megakaryocytic lineage. TSF has been described to be identical with ... ... ... ... ... Subscribe to continue reading! ... ...

 

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