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[tissue inhibitor of metalloproteinases-1; TIMP metallopeptidase inhibitor 1; metalloproteinase inhibitor 1]. TIMP-1 (called originally also just TIMP [tissue inhibitor of metalloproteinases] before the identification of related inhibitors TIMP-2, TIMP-3, and TIMP-4) is a member of a group of tissue inhibitors of metalloproteinases that inhibit matrix metalloproteinases, which are involved in the degradation of the extracellular matrix (see also: TIMP).
TIMP-1 has been identified independently as HCI [human collagenase inhibitor] (also: CLGI [
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