Staphylococcus aureus flr |
Staphylococcus aureus Map |
ADAMTS20 |
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Gamma-toxin, which is known also as Gamma-hemolysin, is one of the exotoxins produced by most isolates of Staphylococcus aureus (Lina et al, 1999). Gamma-toxin is a bi-component pore-forming cytotoxin (Sugawara et al, 1997) composed of non-associated soluble proteins, S and F (Finck-Barbancon et al, 1991; Woodin, 1960). These are encoded by two genes for an S component (hlgA and hlgC) and one gene for the F component, hlgB (Prevost et al, 1995). The individual components alone are not cytotoxic, but components together (hlgA+hlgB and hlgC+hlgB, referred to as Gamma-hemolysin AB (HlgAB) and Gamma-hemolysin CB (HlgCB), are active. The F component (called also H gamma 1) is shared with Streptococcus aureus leukocidin (see: Panton-Valentine leukocidin) (Kamio et al, 1993).
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