STIM1 Deficiency |
Stimulated rat T-cell derived inhibitory factor for cellular DNA |
Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr |
||
[Stromal interaction molecule 2] The gene has been cloned by Williams et al (2001). The cDNA has been identified independently as KIAA1482. STIM2, together with STIM1, acts as a calcium sensor in the endoplasmic reticulum and plays a role in store-operated calcium entry following depletion of endoplasmic reticulum calcium stores (Liou et al, 2005). It has been shown to inhibit calcium entry mediated by STIM1, acting as a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels (Soboloff et al, 2006; Brandman et al, 2007) and mediates distinct store-dependent and store-independent modes of Ca2+ release-activated Ca2+ (CRAC) channel channel activation. (Parvezet al, 2008). Thiel et al (2013) have reported that STIM2 is activated preferentially by low-level physiological agonist
... ... ... ...
... CONTINUE READING at cells-talk.com,
COPE's new home with 61 100+ entries, 141 552 cited references and >2,5
million internal hyperlinks. This most comprehensive knowledge base provides
extensive in-context information covering nomenclature, terminology, and
highlighting concepts, strategies & complexities of cellular communication
processes. COPE's fully integrated subdictionaries include
Dictionary of Angiogenesis •
Dictionary of Antimicrobial & host defense peptides •
Dictionary of Apoptosis and cell death •
Dictionary of CD antigens •
Dictionary of Chemokines •
Dictionary of Cryptides •
Dictionary of Cytokines & Growth factors •
Dictionary of Eukaryotic cell types & expression profiles •
Dictionary of Hematopoiesis •
Dictionary of Hormones •
Dictionary of Inflamation & inflammatory mediators •
Dictionary of Innate Immunity •
Dictionary of Metalloproteinases •
Dictionary of Moonlighting proteins & cryptides •
Dictionary of Neuropeptides •
Dictionary of Pathogenicity & Virulence Factors •
Dictionary of Pattern recognition receptors •
Dictionary of Protein domains •
Dictionary of Regulatory peptide factors •
Dictionary of Viroceptors •
Dictionary of Virokines •
Dictionary of Stem cells
and more.
An important note about your privacy: A search engine may have brought
you here. If the provided URL differs in any way from
"www.copewithcytokines.org/cope.cgi?key=search term", 3rd parties may
record your activities on COPE. Bypass snoopers by doing this: Go
directly to cells-talk.com or go to
copewithcytokines.org
in a new browser tab and from there explore whether COPE contains the terms
that interest you. The private bioinformatics initiative COPE at
cells-talk.com
never shares your search histories or user databank entry with 3rd parties.
SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
# | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R