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STIM2

[Stromal interaction molecule 2] The gene has been cloned by Williams et al (2001). The cDNA has been identified independently as KIAA1482. STIM2, together with STIM1, acts as a calcium sensor in the endoplasmic reticulum and plays a role in store-operated calcium entry following depletion of endoplasmic reticulum calcium stores (Liou et al, 2005). It has been shown to inhibit calcium entry mediated by STIM1, acting as a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels (Soboloff et al, 2006; Brandman et al, 2007) and mediates distinct store-dependent and store-independent modes of Ca2+ release-activated Ca2+ (CRAC) channel channel activation. (Parvezet al, 2008). Thiel et al (2013) have reported that STIM2 is activated preferentially by low-level physiological agonist ... ... ... ...
 
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Entry last modified: September 2019



 
 
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