SPYGFRHGASVNYDDY |
SPY3-2 |
ICOSL |
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[skin peptide tyrosine tyrosine, skin-PYY] This peptide has been isolated from the skin secretions of the South American arboreal frog Phyllomedusa bicolor (Mor et al, 1994). It exhibits 94 % similarity with PYY from the frog Rana ridibunda.
SPYY inhibits alpha-MSH release from perfused frog neurointermediate lobes in very much the same way as NPY (Mor et al, 1994; Vaudry et al (1999).
SPYY irreversibly inhibits the proliferation of a broad spectrum of pathogenic microorganisms and thus may play a role in innate immunity (Vouldoukis et al, 1996).
For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also:
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