SPRYD4

[SPRY domain-containing protein 4] The cDNA encoding this protein has been cloned from a human brain cDNA library (Zhong et al, 2008). SPRYD4 is expressed ubiquitously; it is expressed strongly in kidney, bladder, brain, thymus and stomach, and weakly expressed in liver, testis, uterus, spleen and lung. Zahid et al (2019) have reported that SPRYD4 functions as a tumor suppressor, showing that its expression is downregulated in primary hepatocellular carcinoma tissues compared to non-tumor tissues. SPRYD4 expressio is associated with a good prognosis and its expression becomes downregulated when tumors progress towards more aggressive stages and higher grades. Exogenous SPRYD4 expression inhibits the proliferation of the tumor cells by inducing ... ... ... ...
 
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Entry last modified: April 2019