SPAR
[SP-A recognition protein.] The cDNAs encoding human and porcine SPAR have been cloned by Strayer et al (1993). SPAR is expressed in type 2 pneumocytes, and binding of surfactant protein A to SPAR regulates pulmonary surfactant secretion (White and Strayer, 2000). Engagement of SPAR by surfactant protein A has been reported to activate survival signalling, which may play a role in type 2 pneumocytes repopulating the alveolar epithelium after peripheral lung damage (White MK, Strayer, 2002).
Note that another SP-A receptor with no sequence relationship to SPAR has been idenfied (see: CKAP4 [Cytoskeleton-associated protein 4]).
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Entry last modified: October 2002
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