SOX2
[SOX2(+), SOX2(-), SOX2(high), SOX2(low)]
[SRY box 2; sex determining region Y box 2] also: SRY-related HMG box gene 2. SOX2 (317 amino acids) (Stevanovic et al, 1994) is encoded by a highly conserved single-exon gene. The protein is a member of a family of transcription factors named after SRY [sex-determining region Y] and contains a characteristic HMG box. SOX2 activity has been shown to be associated with the promoter region of 7 % of protein-coding genes in human embryonic stem cells (Boyer et al, 2005). SOX2 activates and represses the expression of different gene sets in various tissues during development, and the cooperation with other transcription factors
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