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HMG box

The HMG box is a DNA binding domain of approximately 70-80 amino acids. It is related to a motif originally identified in HMGB1 (Baxevanis and Landsman, 1995). This sequence motif is found in all members of the HMG box family with some member containing multiple HMG sequence motifs and others containing only one HMG box sequence (Soullier et al, 1999). HMG [high mobility group] proteins are a diverse superfamily of non-histone chromosomal proteins classified originally by their electrophoretic mobility (Goodwin and Johns, 1973). These proteins are involved in bending and unwinding of compacted chromatin structure (Bustin, 1999; Bianchi et al, 1998; Thomas and Travers, 2001).

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