SIRPB1

(approved gene symbol) [signal regulatory protein-beta-1] abbr. also: SIRP-beta-1 [signal regulatory protein-beta-1].

The gene encoding SIRPB1 has been cloned by Kharitonenkov et al (1997). SIRP-beta-1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail (Kharitonenkov et al, 1997). SIRP-beta-1 is expressed on monocytes and granulocytes but not on lymphocytes (Seiffert et al, 2001).

The ligand of SIRP-beta-1 has not been identified. SIRP-beta-1 has been shown to associate with DAP12 (TYROBP [TYRO protein tyrosine kinase ... ... ... ...
 
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Entry last modified: August 2014