similar expression to FGF |
Simple epithelia |
Nlrb1b |
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[signaling molecule that associates with the mouse pelle-like kinase] The approved gene symbol for this protein is IRAK1BP1 [IL1 receptor associated kinase 1 binding protein 1; IRAK1 binding protein 1].
SIMPL has been identified by Vig et al (2001) as a binding partner of IRAK, a kinase associated with the IL1 receptor. Overexpression of SIMPL leads to the activation of NF-kappa-B dependent promoters. Inactivation of SIMPL inhibits IRAK as well as TNF-alpha receptor type 1 induced NF-kappa-B activity. Nuclear localization of SIMPL is required for type 1 TNF-alpha receptor-induced NF-kappa-B
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