SHAP

[serum-derived HA associated protein; serum-derived hyaluronan associated protein] SHAP binds to hyaluronan and hyaluronan fragments and has been shown to correspond to the heavy chains of the Inter-alpha-trypsin inhibitor (ITIH1 [Inter-alpha-trypsin inhibitor H1], ITIH2 [Inter-alpha-trypsin inhibitor H2], ITIH3 [Inter-alpha-trypsin inhibitor H3] (see: ITI) (Huang et al, 1993).

Yamaguchi Y et al (2017) have reported that SHAP is a biomarker for inflammatory bowel disease that is related to disease activity in certain types of colitis and may affect disease pathogenesis.

The formation of covalent SHAP-hyaluronan complexes occurs primarily during ... ... ... ...
 
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Entry last modified: August 2019