ITI
[Inter-alpha-trypsin inhibitor; often also only Inter-alpha-inhibitor] ITI is a serine protease inhibitor of approximately 220 kDa mainly synthesized in the liver and found in human serum at concentrations of 0.4-0.5 g/L. Substrates of ITI include trypsin, chymotrypsin, and a neutrophil elastase.
The inhibitor consists of three evolutionarily related polypeptide chains called heavy chains:
92 kDa Inter-alpha-trypsin inhibitor [Inter-alpha-trypsin inhibitor 92 kDa]; also: ITI-HC1 [Inter-alpha-trypsin inhibitor Heavy Chain 1]; approved gene symbol: ITIH1 [Inter-alpha-trypsin inhibitor H1
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