SCPF
[stem cell proliferation factor] This biochemically uncharacterized factor of 32 kDa (secreted form) and 37 kDa (membrane-bound form) is isolated from a human mixed germ cell tumor (Lawman et al, 1993). Purified SCPF induces the appearance of blast-like cells with a high replating efficiency in clonogenic assays. These cells express the cell surface marker CD34.
SCPF either alone or in combination with IL3 maintains primitive hematopoietic stem cells in short-term and long-term BMC (bone marrow culture). For another "stem cell factor" see: SCF.
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