S100

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S100 is found at high concentrations in astroglial cells of the central nervous system and in discrete neurons in the mesencephalic and motor trigeminal, facial, and lemniscus nuclei. The protein is expressed also in Schwann cells of the peripheral nervous system. The S100 protein subunits, S100-alpha [S100 calcium binding protein-alpha] and S100-beta [S100 calcium binding protein-beta], are expressed selectively by specific cell types. The S100a(0) protein (alpha alpha form of S100) is found predominantly in the cardiac and skeletal muscle of various mammals at much higher levels than in the nervous system. ... ... ... ...
 
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Entry last modified: April 2002