Romurtide

A synthetic muramyl dipeptide (MDP) derivative that is a potent inducer of cytokines (Azuma I et al 1992, 1992). Namba K et al (1997) have reported that Romurtide promotes the development of megakaryocytes and platelets through stimulation of cytokine production in nonhuman primates with myelosuppression.

A derivative, MDP-Lys(L18) = N-alpha-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-N epsilon-stearoyl-L-lysine), called also Muroctasin, is used as a hematopoietic agent for restoration of leukopenia in cancer patients treated with radiotherapy and chemotherapy (see also: hematopoiesis).

Fujimura T et al (2011) have reported that this derivative and IFN-beta synergistically induce dendritic cell ... ... ... ...
 
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Entry last modified: October 2022