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RNF186

[RING finger protein 186] RNF186 is a putative multi-pass membrane protein containing a RING finger domain. The protein is an E3 ligase located in the endoplasmic reticulum and participates in the process of ER stress-mediated apoptosis. Overexpression of RNF186 stimulates upregulation of ER sensor proteins and rapid transmission of ER Ca(2+), whereas knock-down elicits a moderate degree of resistance to ER stress.

The BCL2 family protein BNIP1 [BCL2/adenovirus E1B 19 kDa protein interacting protein-1] has been shown to be poly-ubiquitinated by RNF186. This modification promotes BNIP1 transportation to mitochondria to direct ER stress-associated apoptotic signaling.

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