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RKIP

[RAF kinase inhibitor protein] This protein has been identified by Yeung et al (1999). RKIP inhibits the phosphorylation and activation, by raf1, of MEK, a kinase involved in the activation of extracellular signal-regulated kinases and thus controls cell proliferation and differentiation of different cell types (Trakul et al, 2005; Yeung et al, 1999).

Chatterjee et al (2004) have reported that RKIP expression is upregulated rapidly during induction of chemotherapy-triggered cell death by apoptosis in human prostate and breast cancer cell lines. Maximal RKIP expression correlates with the onset of apoptosis and this upregulation is not observed in ... ... ... ... ... Subscribe to continue reading! ... ...

 

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