RKGWFKAMKSIAKFIAKEKLKEHL |
RKKRRQRRR |
MIP-1-alpha RL1 |
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[RAF kinase inhibitor protein] This protein has been identified by Yeung et al (1999). RKIP inhibits the phosphorylation and activation, by raf1, of MEK, a kinase involved in the activation of extracellular signal-regulated kinases and thus controls cell proliferation and differentiation of different cell types (Trakul et al, 2005; Yeung et al, 1999).
Chatterjee et al (2004) have reported that RKIP expression is upregulated rapidly during induction of chemotherapy-triggered cell death by apoptosis in human prostate and breast cancer cell lines. Maximal RKIP expression correlates with the onset of apoptosis and this upregulation is not observed in
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