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Pore membrane and/or filament interacting like protein 3
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RIS1

[Ras-induced senescence 1] This gene has been identified by Barradas et al (2003) as a gene the expression of which is upregulated specifically in Ras-senescent human fibroblasts. RIS1 is highly conserved in vertebrates, does not present paralogs, and its sequence does not reveal similarities with other proteins or domains. Iglesias et al (2006) have identified RIS1 as a gene with trinucleotide repeats that is a target in the mutator pathway of colorectal carcinogenesis. Nieto et al (2007) have generated knock-out mice lacking expression of RIS1. These mice are viable, fertile, develop normally, and do not display any obvious abnormalities. These mice ... ... ... ... ... Subscribe to continue reading! ... ...

 

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