RET
accronym from rearranged during transfection proto-oncogene, identified by Takahashi et al (1985) as a transforming gene detected after transfection of NIH 3T3 cells with human lymphoma DNA. The human RET gene maps to chromosome 10q11.2 (Ishizaka et al, 1989).
RET is a transmembrane tyrosine kinase containing 4 cadherin-like repeats, a cysteine-rich area, a calcium-binding site on the extracellular region, and several intracellular tyrosine kinase domains (Santoro et al, 2004). Databank synonyms are CDHR16 [cadherin-related family member 16] and CDHF12 [
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