RELT

[Receptor Expressed in Lymphoid Tissues] RELT is a type 1 transmembrane glycoprotein with a cysteine-rich extracellular domain, possessing significant homology to TNFRSF19, DR3, OX40, and the LT-beta receptor. The factor has been designated TNFRSF19L [TNF receptor superfamily member 19-like].

High expression of RELT is seen in hematologic tissues (spleen, lymph node, peripheral blood leukocytes, leukemias and lymphomas). RELT activates the transcription factor NF-kappa-B and selectively binds TRAF1. Immobilized RELT can costimulate T-cell ... ... ... ...
 
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Entry last modified: January 2002