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RBL-2H3

This rat cell line, derived from rat basophilic leukemia, is used widely for studies of mast cell biology and is frequently being referred to as a mast cell cell line (for overview see: Passante and Frankish, 2009). The cells do not require exogenous growth factors such as SCF or IL3 and carry a gain-of-function mutation of Kit, the receptor for SCF (Tsujimura et al, 1995).

RBL-2H3 cells share similarities with basophils and thus are considered to be an imprecise and inappropriate model for mast cell ... ... ... ... ... Subscribe to continue reading! ... ...

 

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