R-spondin-3

[Roof plate-specific spondin-3] abbr. Rspo3. R-spondin-3 is a member of the family of R-spondins, which have been shown to be general modulators of canonical Wnt signaling. The protein is being referred to also as PWTSR [Protein with TSP type-1 repeat] (Chen et al, 2002) and THSD2 [Thrombospondin type-1 domain-containing protein 2]. R-spondin-3 has been identified independently as Cristin-1 [cysteine-rich single thrombospondin domain-containing protein-1] (Nam et al, 2006). The gene has been identified by Chen et al (2002). R-spondin-3 shows ubiquitous expression and is detected in all tumor tissues examined except a lung carcinoma and an ovarian carcinoma. The ... ... ... ...
 
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Entry last modified: December 2013