PTAG

[pituitary tumor apoptosis gene] This gene has been identified in a screen for genes that are differentially methylated in pituitary tumors relative to normal pituitary (Bahar et al, 2004). This gene is known also as RHBDD3 [rhomboid domain containing 3] (approved gene symbol) or C22orf3 [chromosome 22 open reading frame 3].

The gene is not expressed in approximately 20 % of pituitary and non-expression correlates with methylation.

Enforced expression of the gene in AtT20 cells does not influence proliferation or viability but augments cell death by apoptosis in response to treatment with bromocriptine (Bahar et al, 2007). Apoptosis can be inhibited by the ... ... ... ...
 
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Entry last modified: January 2018