PNAS-2 |
PNC-27 |
C1q and tumor necrosis factor related protein 14 |
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PNAS4 is a highly conserved gene found in various organisms from plants to animals. Another designation is FAM152A [family with sequence similarity 152 member A]. The protein is encoded by the C1orf121 gene. The approved gene symbol is DESI2 [desumoylating isopeptidase 2] (previously: PPPDE1 [peptidase domain-containing protein 1]). Another databank designation for this enzyme is Deubiquitinase DESI2.
Xie X et al (2017) have reported that PNAS4 possesses isopeptidase activity against ubiquitin conjugated through Lys 48 and Lys 63. Ribosomal protein S7, RPS7
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