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PEPITEM

[peptide inhibitor of trans-endothelial migration]. This peptide with the sequence SVTEQGAELSNEER (Ser-Val-Thr-Glu-Gln-Gly-Ala-Glu-Leu-Ser-Asn-Glu-Glu-Arg) has been identified by Chimen M et al (2015). The peptide has been reported to correspond to 14-3-3-zeta(28-41) (amino acids 28-41 of 14.3.3-zeta), from which it is generated by proteolytic cleavage. PEPITEM has been found to be secreted by B-cells stimulated with adiponectin. Plasma cells, identified as CD38(+) IgD-IgM(-) CD27(-), secrete higher quantities of PEPITEM compared to naive B-cells or memory B-cells.

PEPITEM specifically inhibits the migration of ... ... ... ...
 
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Entry last modified: October 2022



 
 
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