PC-3

[pheochromocytoma cell-3] The expression of this gene is induced in the rat PC12 cell line during neuronal differentiation by NGF. PC-3 is expressed in vivo in the neuroblast when it ceases proliferating and differentiates into a neuron. Overexpression of PC-3 in NIH 3T3 and PC12 cells leads to marked inhibition of cell proliferation (hence the designation NGF-inducible anti-proliferative protein PC3).

PC3 has been shown to potentiate differentiation induced by NGF and to protect neurons from cell death by ... ... ... ...
 
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