PARL

[Presenilin-associated rhomboid-like] The full-length human cDNA encoding PARL has been cloned by Pellegrini et al (2001). PARL shares significant similarity with the Drosophila melanogaster development regulator Rhomboid. The Saccharomyces cerevisiae homolog of PARL is the inner mitochondrial membrane protein Rbd1 (known also as PCP1). Rbd1 mutants have respiratory defects and disrupted mitochondria. McQuibban et al (2003) have shown that human PARL rescues the yeast Rbd1 mutant.

In some publications and databanks the protein is being referred to also as ... ... ... ...
 
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Entry last modified: May 2023