PACER

[Protein associated with UVRAG as autophagy enhancer]; the approved gene symbol for this protein is RUBCNL [Rubicon-like]. PACER has been identified by Cheng et al (2017) who reported that it plays a role in autophagy processes by promoting autophagosome maturation into autolysosomes, functioning as an antagonist of Rubicon, a protein that negatively regulates autophagy. PACER is crucial for the degradation of hepatic lipid droplets, plays a role in the clearance of protein aggregates and has been shown to be involved in the suppression of Salmonella infection.

Cheng X et al (2019) have reported that PACER integrates mechanisms involved in late stages of autophagy and lipid metabolism. Knock-out ... ... ... ...
 
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Entry last modified: January 2022