P-bodies

[mRNA processing bodies; processing bodies] The term P-bodies was used first for structures found in budding yeasts and identified as cytoplasmic sites of mRNA processing (decapping and 5'-to-3' decay) (Sheth and Parkjer, 2003). In mammalian cells such structures were identified and named GW-bodies, so named because they contain GW182, a protein characterized by glycine (G) and tryptophan (W) repeat-rich domains and a canonical RNA-recognition motif that has been demonstrated to associate with a specific subset of transcripts in HeLa cells (Eystathioy et al, 2002). Sometimes such structures are being referred to as GW/P-bodies but the term P-bodies or ... ... ... ...
 
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Entry last modified: March 2017