Oreochromicin-3 |
orexin A |
Trp-Glu-Arg-Arg-Pro-Phe-Ser-Glu-Asp-Val-Asn-Trp-Gly-Tyr-Glu |
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Oreochromicins are alpha-helical antimicrobial peptides (Oreochromicin-1 (FIHHIIGGLFSVGKHIHGLIHGH), Oreochromicin-2 (FIHHIIGGLFSAGKAIHRLIRRRRR), Oreochromicin-3) (IWDAIFHGAKHFLHRLVNPGGKDAVKDVQQKQ) isolated from tilapia (Oreochromis niloticus) (Acosta et al, 2013). These peptides are expressed constitutively in the brain, heart, head kidney, spleen and gut. The synthetic peptides display a broad-spectrum of antimicrobial activity against Gram-negative, Gram-positive bacteria, and fungi such as Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeuroginosa, Escherichia coli
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