OX2

OX2 (new designation CD200) is a type 1 membrane glycoprotein and a member of the immunoglobulin superfamily. The mouse homolog has been cloned by Boriello et al (1998) who called it MOX2.

The protein is expressed on a broad range of tissues including neurons of the central and peripheral nervous systems, thymocytes, and endothelial cells (Wright et al, 2001). OX2 binds to a receptor expressed on macrophages (Preston et al, 1997). Borriello et al (1997) have reported that OX2 can costimulate murine T-cell proliferation.

Knock-out mice lacking expression of OX2 have more ... ... ... ...
 
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Entry last modified: January 2005