ORFV059 |
ORFV2-VEGF |
BLAME |
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This protein is encoded in the genome of orf virus and is a virion protein unique to parapoxviruses. ORFV073 functions very early in infected cells and blocks activation of transcription factor NF-kappa-B. Infection with ORFV073 gene deletion virus increases the accumulation of NEMO, causes marked phosphorylation of the IKK-alpha / IKK-beta complex, I-kappa-B-alpha and NF-kappa-B subunit p65, and early nuclear translocation of NF-kappa-B-p65 in virus-infected cells. Expression of ORFV073 alone is sufficient to inhibit NF-kappa-B signaling induced by TNF-alpha in uninfected cells. Infection of sheep
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