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OIP-1

[osteoclast inhibitory peptide-1] The cDNA for the gene encoding this protein of 131 amino acids was isolated from a human osteoclast-like multinucleated cell (MNC) cDNA library. OIP-1 is a glycosyl phosphatidyl inositol (GPI)-anchored protein that can be released into the medium as a membrane-bound (vesicle form) GPI-linked protein, which suggests an activity as an autocrine and paracrine regulator. The protein acts as a specific inhibitor of osteoclast formation and bone resorption and significantly reduces the formation of osteoclasts in mouse and human BMC (bone marrow culture ... ... ... ... ... Subscribe to continue reading! ... ...

 

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