NHEMs |
NHQQQNPHQPPM |
Necrosin |
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[Neisseria meningitidis hia/hsf homologue A] NhhA is a conserved outer membrane protein of Neisseria meningitidis, a pathogen that is the leading cause of meningitis and septicemia worldwide. It is homologous to the Hia and Hsf adhesins of Haemophilus influenzae (Peak et al, 2000). The C-terminal domain of NhhA is able to trimerize and form a translocator domain that allows localization of the protein to the bacterial surface (Scarselli et al, 2006). Meningococci lacking NhhA are more sensitive to complement-mediated bacterial killing in human serum and can be more easily phagocytosed by macrophages. NhhA also promotes the interaction between capsulated, wild-type meningococci and macrophages
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