NSILA
[non-suppressible insulin-like activity] This factor has been identified by virtue of its ability to stimulate metabolic actions of insulin that could not be inhibited by antibodies directed against insulin (Froesch et al, 1966; Froesch et al, 1979).
NSILA actually is a collective term for activities that can be resolved into two different components (for a historical overview see also: Van den Brandee, 1999). Rinderknecht and Humbel (1978, 1978) have determined the primary structure of the two components of NSILA and termed them IGF-1 [Insulin-like growth factor-1] and IGF-2 [Insulin-like growth factor-2] because of their close similarity to the proform of insulin.
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