NK-LAK cells |
NK-LCF |
FFGWLIKGAIHAGKAIHGLIHRRRHamide |
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[NK lytic-associated molecule] The gene encoding this protein has been cloned by Kozlowski et al (1999). NKLAM is known also as IBRDC3 [IBR domain containing protein 3] or, as it contains a RING finger domain, RNF19B [RING finger protein 19B], which is the approved gene symbol.
The NKLAM gene encodes a 62 kDa RING finger containing protein that localizes to the cytoplasmic granules in NK-cells. The expression of NKLAM is observed in NK-cells after stimulation with cytokines such as IL2 and IFN-beta. NKLAM is expressed also by activated macrophages and
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