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[Neuroendocrine regulatory peptide-3] NERP-3 (QQETAAAETETRTHTLTRVNLESPGPERVW with N terminal pyroglutamylation) is a biologically active peptide derived from the neurosecretory protein VGF. Rat NERP-3 corresponds to VGF(180-209). It is secreted by an endocrine cell line. NERP-3 is identified in acid extracts of rat brain and gut as a 30-residue NERP-3 with N-terminal pyroglutamylation. It is more abundant in the brain, including the posterior pituitary, than in the gut. Intracerebroventricular administration of NERP-3 in conscious rats induces Fos expression in a subset of neurons containing arginine-vasopressin. NERP-3 causes a significant release of ... ... ... ... ... Subscribe to continue reading! ... ...


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