Myxoma virus M11L protein |
myxoma virus M143R protein |
PYPAF1 |
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This 15 kDa protein is encoded in the genome of the lethal, rabbit-specific poxvirus Myxoma virus. The cytoplasmic protein is expressed late during infection. M130R is not essential for virus replication in rabbit, monkey or human cell lines. Viruses lacking M130R are attenuated. The loss of M130R expression allows the rabbit host immune system to effectively respond to and control the lethal effects of virus infection, demonstrating that the protein is a virulence factor necessary for full and lethal development of myxomatosis (Barret et al, 2009).
For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.
For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also:
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