metastasomes |
Metastin |
Leu3 |
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This hyaluronan-binding complex has been isolated from bovine cartilage. Metastatin has antitumorigenic and anti-angiogenic properties. It blocks the formation of tumor nodules in the lungs of mice inoculated with B16BL6 melanoma or Lewis lung carcinoma cells. Single intravenous administration of Metastatin into chicken embryos inhibits the growth of B16BL6 mouse melanoma and TSU human prostate cancer cells growing on the chorioallantoic membrane. Metastatin inhibits the migration and proliferation of cultured endothelial cells and angiogenesis induced by VEGF in a chicken chorioallantoic membrane assay.
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